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Carcinogenesis Inside a life span carcinogenicity analyze completed in B6C3F1 mice, methylphenidate triggered a rise in hepatocellular adenomas, and in males only, a rise in hepatoblastomas in a everyday dose of approximately 60 mg/kg/day. This dose is close to two instances the MRHD of 60 mg/day given to young children on mg/m2 basis.Nobody likes